Site Report

Tokyo Research Park

History

• *
  Please see the following for information on research and development.

Environmental and Safety Activities

Initiatives to Address Climate Change (Prevent Global Warming)

• Since April 2013, Tokyo Research Park has continuously investigated various energy conservation measures as a Designated Global Warming Measure Site under the Tokyo Metropolitan Environmental Security Ordinance, and has implemented global warming measures in a way that connects to real-world implementation. These efforts resulted in a significant decline in CO₂ emissions that exceeded the mandatory reductions stipulated for a Designated Global Warming Measure Site, and in 2022, we were removed as a Designated Global Warming Measure Site. As part of these activities, Tokyo Research Park offered the emissions reduced during the first and second planning periods as credits for the Carbon Offset Program for the Tokyo 2020 Games in August 2020, and cooperated in realizing Tokyo Zero Carbon 4 Days in 2020.
• As a worksite, we regularly hold Energy Conservation Measure Meeting to confirm energy monitoring and energy conservation measure results, as well as to review new measures. More recently, the Committee optimized the operational conditions and controls for air conditioner cooling and heat-source equipment, revised the conditions for laboratory air conditioners, and reviewed the use of lighting. Including efforts to address average monthly temperature fluctuations, this initiative also finely tunes the conditions as the situation requires, and produced energy-saving results.
• Tokyo Research Park has acted to introduce high-efficiency equipment with a low environmental impact for newly purchased equipment and research apparatus.

Initiatives to Prevent Air Pollution

• City gas has been used for boiler facilities thereby eliminating the emissions of SOx and dust.
• Odorous exhaust discharged during the experimentation process is cleaned with a scrubber and release into the atmosphere.

Initiatives to Prevent Water Pollution

• Recognizing water pollution prevention as a particularly important initiative, we provide employee education each year.
• With a particular focus on preventing the release of harmful substances, after collecting waste liquids containing harmful substances that exceed legal standard concentrations, we outsource disposal to a specialized waste disposal company.
• We engage in thoroughgoing wastewater treatment management by conducting regular wastewater measurements and facility inspections.

Initiatives to Reduce Waste

• We are working to avoid the use of organochlorine solvents from the research stage.
• We are working to reduce industrial waste by reusing used equipment and other devices used in research activities and diverting them as valuable resources.
• We are promoting the recycling of waste into resources by selecting waste disposal companies that can utilize material recycling and other recycling methods that have a lower environmental impact.
• We have achieved Zero emission^* status every year.

• *
  Zero emission: Kyowa Kirin Group uses the term to mean a reduction in the amount of waste disposed in landfills to no more than 0.1% of generated waste.

Compliance with the PRTR Act

• PRTR substances (including Class I Designated Chemical Substances) are properly managed, and the emissions of PRTR substances in 2022 were at a level that does not require reporting to the government.

Other Initiatives

• In order to strengthen environmental awareness among all employees, we actively provide regular environmental education, request explanations on and support for energy conservation activity results, and conduct visits to environment-related facilities at each worksite.
• We promote green purchasing by pursuing the use of environmentally-friendly products.
• As clean-up activities in the surrounding area, we conduct clean-up efforts at the nearby Machida Chuo Park, and participate in the Sakai River clean-up activity organized by an outside organization. We have also expanded the scope of our efforts to give back to the community by creating flower beds using part of the grounds.

Sakai River Clean-up Activity

Flower Bedding Activities

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  Please see the following for information on energy intensity, CO₂ emissions, waste volumes, and other data.

Fuji Site (Fuji Research Park and CMC R&D Center)

History

• *
  Please see the following for information on research and development.

Environmental and Safety Activities

Initiatives to Address Climate Change (Prevent Global Warming)

• We have been purchasing RE100-compliant power since January 1, 2022, and have switched over all electricity used to renewable energy.
• We installed solar power generation facilities, which are used to supply electricity.
• In 2019, Fuji Research Park launched the Energy Management Subcommittee, which has acted to monitor energy use and review new energy conservation measures. It selects more efficient equipment when updating equipment.
• We have produced energy conservation results by optimizing large-scale air conditioning equipment through a review of operating conditions and scheduling, and by switching over lighting to LED fixtures.

Initiatives to Prevent Air Pollution

• We use city gas, which emits no sulfur oxides, as the fuel for small boilers.

Initiatives to Prevent Water Pollution

• Each year, we hold emergency response training drills in preparation for wastewater incidents, and review emergency response procedures as necessary. In 2020, we began providing employee education regarding wastewater.
• The Energy Management Subcommittee also engages in water resource protection, monitors water intake, and implements water conservation measures.
• To ensure thorough wastewater treatment management, regular wastewater measurements and facility inspections are conducted.

Initiatives to Reduce Waste

• Having positioned waste as an important environmental issue, we have provided waste-related education to employees since 2021.
• Along with efforts to reduce waste volumes, we promote recycling through thorough waste separation, and have achieved Zero emission^* status.

• *
  Zero emission: Kyowa Kirin Group uses the term to mean a reduction in the amount of waste disposed in landfills to no more than 0.1% of generated waste.

Compliance with the PRTR Act

• Along with reducing the use of substances subject to the PRTR Act, we strive to reduce the amount of these substances released to the atmosphere. Until now, we have reduced use of regulated substances by updating solvent recovery equipment and changing experimental systems.

• Although Fuji Site uses other PRTR Act-designated Class 1 Chemical Substances besides acetonitrile, the amounts fall below those requiring reporting to the government.

Other Initiatives

Global Environment Conservation Initiatives

• While cooperating with local communities through participation in the Ayutsubo Waterfall Vicinity Clean-up Activity, River Friendship Kise River Clean-up Event, and Mt. Fuji Trash Reduction Operation, we have engaged in nearby regional environment conservation.

Ayutsubo Waterfall
(Izu Peninsula Geopark, certified as a UNESCO Global Geopark in April 2018)

• We regularly conduct environmental patrols within and around the grounds.
• We promote green purchasing by pursuing the use of environmentally-friendly products.

• *
  Please see the following for information on energy intensity, CO₂ emissions, waste volumes, and other data.

• Not applicable

Takasaki Plant (including Bio Process Research and Development Laboratories)

History

1. *1:
   News Release : Kyowa Kirin Takasaki Plant opened the Nursery School as a company-led daycare facility (in Japanese only)
2. *2:
   News Release : Kyowa Kirin Completed Construction of a Multipurpose Facility Relating to Quality Assurance (Q-TOWER) at Takasaki Plant
3. *3:
   GMP : Good Manufacturing Practice : A summary of the requirements for meeting established quality standards in the manufacture of pharmaceutical products and for proper control of the manufacturing process of such products.

Cell Culture Tank

Active Pharmaceutical Ingredient Refining Process

Formulation and Filling Process

Q-TOWER

• *
  Please see the following for information on research and development.

Environmental and Safety Activities

Initiatives to Address Climate Change (Prevent Global Warming)

• Under the leadership of the Energy Conservation Liaison Meeting, Takasaki Plant has updated equipment and reviewed equipment use and management in an effort to reduce energy usage.
• We installed solar power generation facilities on the premises, which are used to supply electricity.
• We have undertaken activities to improve awareness of energy conservation. This includes awarding employees for their initiatives to reduce energy.
• We regularly inspect chlorofluorocarbon gas charging equipment in an effort to prevent leaks.
• Since January 2020, we have switched over 75% of the electricity used by the Takasaki Plant with RE100-compliant electricity that emits no CO₂. Since January 2023, we have expanded and introduced RE100-compliant power for all electricity used at the Takasaki Plant^*.

• *:
  News Release:
  Kyowa Kirin signs up to "Aqua Premium" in a first for pharmaceutical manufacturing industry (in Japanese only)
  Kyowa Kirin Has Introduced RE100 Renewable Electricity to All Purchased Electricity at Its Two Plants and Three Laboratories

Initiatives to Prevent Air Pollution

• emit any SOx or dust. Moreover, we regularly update and inspect boilers to further curb environmental impacts, and to use steam more efficiently.

Initiatives to Prevent Water Pollution

• Along with expanding manufacturing equipment, Takasaki Plant installed additional wastewater treatment facilities and introduced membrane treatment equipment in 2009, 2016, and 2022, thereby enhancing its ability to treat wastewater, which has a high load variability.
• We implement thorough wastewater treatment management by conducting regular wastewater measurements and facility inspections.
• Having positioned water pollution as an important environmental issue, we provide regular education to our employees.

Initiatives to Reduce Waste

• By reducing and recycling industrial waste, Takasaki Plant has continued to achieve Zero emission^* status.

• *
  Zero emission: Kyowa Kirin Group uses the term to mean a reduction in the amount of waste disposed in landfills to no more than 0.1% of generated waste.

Compliance with the PRTR Act

• Although Takasaki Plant uses PRTR Act-designated Class 1 Chemical Substances, the amounts fall below those requiring reporting to the government.

Other Initiatives

• With the goal of strengthening environmental awareness among employees and of fully eliminating environmental accidents, Takasaki Plant provides detailed environmental education. Moreover, it engages in environmentally-friendly construction work.
• We promote green purchasing by pursuing the use of environmentally-friendly products.

• We conduct clean-up activities in the vicinity of the Takasaki Plant and volunteer clean-up activities in the vicinity of Kannonyama in Takasaki City, and engage in local environmental conservation activities.

Volunteer Kannonyama Vicinity Clean-up Activity

• Along with aspiring to a leading environmental plant suited to Gunma Prefecture’s abundance of nature, Takasaki Plant is actively engaged in local environmental initiatives, including the Takasaki Water Source Forest Activity^* as a water resource conservation activity.

Takasaki Water Source Forest Activity

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  Takasaki Plant’s ongoing forest conservation activities (Water Source Forest Activity) through weeding and improvement cutting for over 10 years within the forest reserve of Kurabuchi-cho, Takasaki City, were recognized as an effort to preserve and nurture green forests of Gunma Prefecture. As a result, we were awarded the Gunma Prefecture Environmental Award (Environmental Achievement Award) in the past.

• *
  Please see the following for information on energy intensity, CO₂ emissions, waste volumes, and other data.

Ube Plant

History

Granulation Process

Inspection Process

Packaging Process

• *
  Please see the following for information on production at the Ube Plant. (in Japanese only)

Environmental and Safety Activities

Initiatives to Address Climate Change (Prevent Global Warming)

• We introduced a solar power generation facility based on the PPA method on March 1, 2023, which has begun supplying electricity to each plant building and to the new office building. In addition, on April 1, 2023, we switched over all purchased electricity to RE100-compliant renewable energy^*1.
• The SF building achieved net-zero primary energy consumption (derived from fossil fuels) and received the highest rank of "ZEB" certification (the third case in Yamaguchi Prefecture)^*2.
• Given the risk of storm surges associated with extreme weather events and rising sea levels, the main facilities and site are surrounded by a tidal embankment to ensure the safety of employees and a stable supply of pharmaceutical products.
• We have acted to introduce high-efficiency equipment with a low environmental impact for newly installed and updated equipment.

• *1:
  News Release: Kyowa Kirin Has Introduced RE100 Renewable Electricity to All Purchased Electricity at Its Two Plants and Three Laboratories
• *2:
  News Release: Kyowa Kirin Completed Construction of a New Office Building at Ube Plant

Initiatives to Prevent Air Pollution

• Ube Plant is acting to prevent air pollution by introducing kerosene boilers that do not emit any sulfur oxides.

Initiatives to Prevent Water Pollution

• Along with separating and treating waste liquids that have a high environmental impact as industrial waste, Ube Plant installed sensors (TOC, pH, temperature) along wastewater channels as part of a system that collects waste liquid and prevents it from escaping to the outside in the event of an irregularity. We also act to prevent water pollution of public waters by conducting training and education that assumes the occurrence of an irregularity.
• Rainwater discharged from the Ube Plant site into rivers is collected in a rainwater drainage tank, and the quality of the rainwater drainage is continuously monitored using pH meters and oil film meters.
  When an irregularity is detected, a movable gate within the rainwater drainage system operates to switch the drainage channel and collect the rainwater in an emergency inflow tank as a means of preventing the risk of irregular rainwater from being discharged to rivers (environmental accident).

Initiatives to Reduce Waste

• By recycling industrial waste, Ube Plant has continued to achieve Zero emission^* status since FY2004.

• *
  Zero emission: Kyowa Kirin Group uses the term to mean a reduction in the amount of waste disposed in landfills to no more than 0.1% of generated waste.

Compliance with the PRTR Act

• Although Ube Plant uses PRTR Act-designated Class 1 Chemical Substances, the amounts fall below those requiring reporting to the government.

Other Initiatives

• In order to foster and maintain its water sources, Ube Plant conducts forest thinning, pruning, weeding, and other activities in the vincinity of the Mito District water source and Akiyoshidai. It also actively engages in clean-up activities in nearby communities, and conducts beautification and clean-up activities in the area around the plant each month.
  
• We regularly provide environmental education for all plant employees in order to promote a greater awareness of the environment.
• We promote green purchasing by pursuing the use of environmentally-friendly products.
• We participate in community volunteer activities and conduct SDGs campaigns within the plant as needed.